Professional All-Trans Retinol
Induction Therapies didn't discover retinol when it became popular. We built microencapsulated All-Trans Retinol formulas around it, from nightly home care to in-office treatment.
The formulation story
Y.E.S.S.® pairs encapsulated 1% All-Trans Retinol with trichloroacetic acid and hyaluronic acid. The retinol is the ingredient. Keeping it stable, tolerable, and effective beside an acid is the formulation.
Retinol bound to a fatty acid, such as palmitate or acetate. It must be hydrolyzed back to retinol before conversion begins, and retinyl palmitate is only about 55% retinol by weight.[1][2]
The alcohol form of vitamin A (C₂₀H₃₀O, 286.46 g/mol). Two oxidation steps from the active form, one reason retinol is better tolerated than retinoic acid.[1][2]
Formed when skin oxidizes retinol. One step from retinoic acid.[1]
Tretinoin. Acts on retinoid receptors directly, needs no conversion, and is prescription-only as a topical drug.[1]
Five variables, one result
Not an ester. Esters need an extra conversion step and carry less retinol by weight. Y.E.S.S.® pairs All-Trans Retinol with trichloroacetic acid in one daily step.[1][2]
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Microencapsulation shields retinol from oxygen and light and moderates how much reaches the skin at once. In Pearls of Retinol, the encapsulated retinol is visible as suspended pearls.[4]
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Plant XO pads use 0.5% and 1.0% for home renewal. Pro Plant XO uses 4.0% and 8.0% inside supervised in-office protocols. Different tools, not just different strengths.
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PRX⁸ combines Plant Exosomes and copper tripeptides with micro-encapsulated All-Trans Retinol (0.5%), formulated for the recovery window after a procedure.
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Plant XO pairs All-Trans Retinol with amino acids, the building blocks of collagen, and Plant Exosomes.
View ProductInside the formula
Retinol only works if patients can keep using it. We formulate for retinoid activity and skin tolerance at once.
The molecule
C₂₀H₃₀O · vitamin A alcohol
"All-trans" describes geometry: four conjugated double bonds in the side chain, all trans. UV and heat can twist them into cis isomers. Pure retinol is pale yellow, so the color of these pads is the retinol.[2]
More retinol survives to reach the skin.
Released over time, not all at once.
Conceptual illustration of retinol at the skin surface over time, not measured release data.[4]
Less irritation, so patients keep going.
Retinoid irritation is dose-dependent. In studies of encapsulated retinoids, slower release was associated with less irritation.[4]
A tolerable start makes progression possible.
1% retinyl palmitate is only about 0.55% retinol by weight. And Plant XO at 0.5% / 1.0% for home use versus Pro Plant XO at 4.0% / 8.0% in-office are different tools, not just different strengths.[2]
An example progression
A tolerable start makes progression possible. The provider sets the pace, and many patients stay at maintenance long term.
Retinol quiz
You prescribe it. Recommend it. Maybe even use it every night. But how well do you actually know retinol?
Applications
From the retail shelf to the treatment chair. Select an application.
A slow-release nightly serum patients can sustain for years, starting a few nights a week.
View ProductEncapsulated retinol with TCA and hyaluronic acid for discoloration and uneven texture.
View ProductAt-home retinol peel pads with Plant Exosomes that keep renewal going between appointments.
View Product4.0% and 8.0% pads that promote controlled peeling within a provider-led protocol, with post-care.
View ProductApplied in the treatment room after a procedure, then continued at home through the recovery window.
View ProductClinical evidence
Single-site, open-label pilot at Tennessee Clinical Research Center. 22 women enrolled, ages 41–60, Fitzpatrick II–IV, Glogau II–III; nightly use with IT Cleanse and Block IT SPF30 for 12 weeks; Visia CR imaging. Subject-reported lines, wrinkles, and discoloration improved in 38.1% of subjects; not significant. Dr. Gold is a consultant to Induction Therapies, and the research center was compensated. Read the study (PDF)
Characterization: NanoFCM, commissioned by the manufacturer; PRX⁸ median particle size 66.2 nm, 62% membrane-positive. Case report: Rafael E. Mojica, DO, FAAD, and Shino Aguilera, DO (affiliated with Induction Therapies). 62-year-old patient who had failed hydroquinone and tranexamic acid; 2-month washout; daily sunscreen. Retrospectively estimated scoring; the authors call for controlled studies. Microneedling device claims are outside the scope of this page. Case report (PDF) · NanoFCM report (PDF)
Case stories
The portfolio
Ordered by where each formula belongs in a retinol strategy.
The alcohol form of vitamin A. Skin converts it to retinaldehyde and then to retinoic acid, the active form. Those two conversion steps are one reason retinol is better tolerated than prescription retinoic acid.
Retinyl palmitate is an ester: retinol bound to a fatty acid. It must be converted back to retinol first, and 1% retinyl palmitate is only about 0.55% retinol by weight.
Retinol is degraded by light, heat, oxygen and acids. Encapsulation protects it and releases it over time, and slower release is associated with less irritation.
For home care: Plant XO pads at 0.5% and 1.0%, Pearls of Retinol, Y.E.S.S.® and PRX⁸. For professional in-office use only: Pro Plant XO pads at 4.0% and 8.0%.
Yes. Y.E.S.S.® was evaluated in a 12-week, open-label pilot study in which 21 women completed nightly use. The study design, results and disclosures are linked on this page.
Yes. Retinol absorbs UV light, which breaks it down, so apply it in the evening and use broad-spectrum SPF 30 or higher every day.
Yes. We handle formulation, branding, packaging and production in our FDA-inspected facility. Start with the private-label intake form or call 877-746-4407.
Private label
Years of All-Trans Retinol formulation, under your practice's name. We handle formulation, branding, packaging, and production in our FDA-inspected facility.
Cosmetic products. Individual results vary. Use broad-spectrum SPF 30 or higher during the day while using retinol. Pro Plant XO 4.0% and 8.0% are for professional in-office use only.
